I have only had my 2017 for a week today, still trying to figure it out. I have kept it on Automatic. Filled up for the first time this morning. On the first tank I got 465 miles; however I didn't start charging at work until Wednesday and I didn't figure out EV in town/hybrid on the highway until Tuesday so I imagine I'll do better on subsequent tanks. Last weekend, for example, I didn't realize the car is in EV by default and pretty much ran the battery down before it switched over to the engine.
I commute 37 miles to work so going from a 27 MPG Ford Fusion to this is already a dream.